INFeD® improved the hemoglobin response to erythropoietic therapy in have been reported after administration of iron dextran injection, the drug should be. iron dextran – Drug Summary. Jump to INFeD Intramuscular Inj Sol: 1mL, 50mg . INFeD: INFeD is administered by intramuscular or intravenous injection. Allergan, Inc.: Intravenous or intramuscular injections of INFeD are indicated for treatment of patients with documented iron deficiency in whom.
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In normal, healthy adults, some daily loss of iron occurs through normal skin, hair, and nail loss, and GI losses. Specific guidelines for dosage adjustments in renal impairment are not available; it appears that no dosage adjustments are needed.
There are limits to the volume of iron dextran that may be injected IM per 24 hours based on patient age and weight; see inted guidelines. An In Vitro Study.
It should be remembered that iron deficiency anemia will not appear until essentially all iron stores have been depleted. Serum iron, total iron binding capacity TIBC and percent saturation of transferrin are other important tests for detecting and monitoring the iron deficient state. Oral iron supplementation should be discontinued before parenteral administration of iron. If test dose uneventful, give the remainder of the total dose as 50 mg of iron dextran per day IM or slow IV until the total calculated dose is given.
Do not mix INFeD with other medications or add to parenteral nutrition solutions for intravenous infusion. To restore hemoglobin and replenish iron stores due to blood loss. Patients with a history of drug allergy may be at increased risk for anaphylactoid reactions.
INFeD (iron dextran) dose, indications, adverse effects, interactions from
Transferrin delivers iron to specific receptors for deposit, where it is either incorporated into hemoglobin or oxidized and stored in combination with apoferritin as ferritin. Inject deeply into the upper outer quadrant of the buttock gluteus maximus only using a 2- or 3-inch, or gauge needle. Isoproterenol or similar beta-agonist agents may be required in these patients. Iron lnsert the placenta, and pregnancy increases iron-intake requirements.
Parenterally administered iron does not give a faster response compared to oral administration, therefore, the rate of recovery from anemia should be the same. Before administering therapeutic doses by any route, a test dose of 25 mg 0. Give INFeD test doses gradually over at least 30 seconds. General Unwarranted therapy with parenteral iron will cause excess storage of iron with the consequent possibility of exogenous hemosiderosis.
packagee Iron dextran should only be used in patients with a clear and confirmed need for parenteral iron therapy. Parenteral administration of iron dextran may exacerbate joint pain and swelling in patients with rheumatoid arthritis, ankylosing spondylitis, or systemic lupus erythematosus SLE.
Since deferiprone has the potential to bind polyvalent cations e. Inject via slow IV at a gradual rate not to exceed 50 mg 1 mL per minute for adults; take care to inject dosage very slowly in children and infants.
The use of iron dextran to prevent iron deficiency in patients requiring long-term parenteral nutrition support is controversial; some experts advocate the use of iron to treat a deficiency if it occurs vs. Pediatric Use Alternatively the total dose may be calculated: Because anaphylactic reactions are known to occur after uneventful test doses, subsequent test doses should be considered.
Iron dextran (INFeD)
Transferrin eventually becomes available for reuse. Total Dose Intravenous Infusion : There is some concern that intravenously administered iron is not used appropriately by the body.
Teratogenic and embryocidal effects are seen at doses roughly 3 times the maximal human dose. Slow intermittent intravenous IV injection: March Product No.: Adult and Adolescent menstruating, premenopausal women.
Parenteral iron supplement of ferric oxyhydroxide complexed with dextrans; rapidly repletes packagge stores in deficiency from anemia or blood loss; sometimes associated with severe hypersensitivity. Alternatively the total dose may be calculated:. Iron content of hemoglobin.